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The three main layers of the hair shaft are the:

  1. Cuticle, Cortex, & Medulla

  2. Dermis, Epidermis, & Endodermis

  3. Root, Shaft, & Tip

  4. Follicle, Bulb, & Papilla

The correct answer is: Cuticle, Cortex, & Medulla

The three main layers of the hair shaft are the cuticle, cortex, and medulla. Option B is incorrect because it refers to layers of skin rather than hair. Option C is incorrect because it refers to the location of the hair rather than the layers. Option D is incorrect because it refers to structures involved in hair growth rather than layers of the hair shaft. Therefore, option A is the correct answer as it accurately describes the layers of the hair shaft.