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What do the skin and its appendages make up?

  1. Skeletal system

  2. Circulatory system

  3. Integumentary system

  4. Nervous system

The correct answer is: Integumentary system

The skin and its appendages make up the integumentary system. This system primarily functions as a barrier to protect the body against harmful substances, infections, and physical damage. The skin is also involved in the regulation of body temperature and the production of Vitamin D. While the skeletal system (Option A) includes bones and joint, the circulatory system (Option B) involves the transport of materials around the body, and the nervous system (Option D) is responsible for controlling body functions and sending messages between the body and the brain, none of these systems include the skin and its appendages. Therefore, these options are incorrect. The correct answer is option C, the integumentary system.